Asceneuron Secures $100 Million Series C Financing to Advance Groundbreaking Therapeutics in Neurodegenerative Diseases

Asceneuron Secures $100 Million Series C Financing to Advance Groundbreaking Therapeutics in Neurodegenerative Diseases

Asceneuron Secures $100 Million Series C Financing to Advance Groundbreaking Therapeutics in Neurodegenerative Diseases

  • Financing led by Novo Holdings, including new investment from EQT Life Sciences – LSP Dementia Fund, OrbiMed and SR One with participation from existing investors M Ventures, Sofinnova Partners, GSK Equities Investments Limited and Johnson & Johnson Innovation – JJDC, Inc.
  • Funds will be used to progress lead asset ASN51, an oral small molecule OGA inhibitor, into Phase 2 clinical development for the treatment of Alzheimer’s disease

Lausanne, SWITZERLAND and San Francisco, CA, USA, 16 July 2024

Asceneuron SA, a clinical stage biotech company developing small molecules targeting tau protein aggregation, a root cause of neurodegenerative disease, today announces an $100 million oversubscribed Series C financing to advance the clinical development of its groundbreaking clinical pipeline of OGA inhibitors for the treatment of neurodegenerative diseases. The financing was led by Novo Holdings with new investment from EQT Life Sciences – LSP Dementia Fund, OrbiMed and SR One, alongside participation from existing investors M Ventures, Sofinnova Partners, GSK Equities Investments Limited and Johnson & Johnson Innovation – JJDC, Inc.

The financing will be used to advance Asceneuron’s lead asset ASN51 into Phase 2 clinical development for the treatment of Alzheimer’s disease. ASN51 is an oral small molecule drug designed to inhibit OGA, an enzyme implicated in protein aggregation. By preventing the aggregation of tau proteins, ASN51 aims to slow the progression of Alzheimer’s disease. OGA inhibition has also shown promising potential to prevent the aggregation of proteins that are central to other neurodegenerative diseases, including Parkinson’s disease and amyotrophic lateral sclerosis.

ASN51’s unique mode of action and convenient oral formulation make it an ideal therapy for patients with Alzheimer’s disease. Asceneuron has completed five Phase 1 clinical trials, demonstrating complete central nervous system uptake and high OGA enzyme occupancy. Asceneuron plans to initiate its first Phase 2 clinical study later this year.

Barbara Angehrn Pavik, Chief Executive Officer of Asceneuron, said:
“This high caliber life sciences investor syndicate further validates the potential of our OGA inhibitor pipeline and leadership in the field of tauopathies. We are excited to advance our lead asset ASN51 into Phase 2 clinical development, recognizing its potential to significantly expand treatment options for patients with Alzheimer’s disease.”

Naveed Siddiqi, MD, Senior Partner, Venture Investments, Novo Holdings, commented:
Alzheimer’s disease is undergoing a transformational moment. Millions are afflicted by this devastating disease and there are very few therapeutic options. Validated biomarkers are allowing for more focused and rapid development. We are now witnessing the approvals of the first disease modifying antibody based injectable therapies. Asceneuron’s innovative oral small molecule drug targeting intracellular tau offers the potential for a paradigm shift in the way this neurodegenerative disease is treated.”

Hakan Goker, PhD, Managing Director of M Ventures, the founding investor of Asceneuron, remarked on behalf of the existing investors:
“Asceneuron has successfully developed highly differentiated oral OGA inhibitors from pre-clinical development to where they are today, entering Phase 2 development in patients with Alzheimer’s disease. ASN51 holds great promise as a next generation treatment for Alzheimer’s disease in addition to addressing other neurodegenerative diseases, including Parkinson’s disease and amyotrophic lateral sclerosis. Together with the current blue-chip investors like Sofinnova Partners, who led the series A round, we welcome the new strong investor group to continue supporting the company in this significant phase of development.”

 

In connection with the financing, Naveed Siddiqi of Novo Holdings, Philip Scheltens of EQT Life Sciences – LSP Dementia Fund and Dina Chaya of OrbiMed will join the Asceneuron board of directors, chaired by Abbas Hussain. Amit Shah, board director, will now represent new investor SR One (previously representing GSK). These Board directors join existing investor directors, Henrijette Richter of Sofinnova Partners and Hakan Goker of M Ventures.

 

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For further information, please contact:

Asceneuron
Barbara Angehrn Pavik, CEO
Sandra Millet, Head of Operations
Email: asce-contact@asceneuron.com

Optimum Strategic Communications
Mary Clark, Zoe Bolt, Joshua Evans
Tel: +44 20 388 296 21
Email: asceneuron@optimumcomms.com

About Asceneuron

Asceneuron is a clinical stage biotech company focused on the development of orally bioavailable therapeutics for debilitating neurodegenerative disorders with high unmet medical need. The company’s pipeline reflects its ambition and commitment to developing treatments for a wide range of neurodegenerative diseases. Asceneuron has two clinical-stage small molecule OGA inhibitors in development: ASN90 (licensed to Ferrer Pharmaceuticals) for the treatment of progressive supranuclear palsy (PSP) and a potential best-in-class molecule, ASN51, for Alzheimer’s disease. The company is also planning to advance its pre-clinical development pipeline in Parkinson’s disease, amyotrophic lateral sclerosis (ALS) and other neurodegenerative indications. Asceneuron is backed by a renowned syndicate of investors consisting of EQT Life Sciences – LSP Dementia Fund, GSK Equities Investments Limited, Johnson & Johnson Innovation – JJDC, Inc., Kurma Partners, M Ventures, Novo Holdings, OrbiMed, Sofinnova Partners and SR One. For more information, please visit www.asceneuron.com.

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Asceneuron Joins Critical Path for Alzheimer’s Disease Consortium

Asceneuron Joins Critical Path for Alzheimer’s Disease Consortium

Asceneuron Joins Critical Path for Alzheimer’s Disease Consortium

  • Consortium brings together industry, academic, and regulatory experts to advance research and bridge gaps in drug development targeting Alzheimer’s disease
  • Asceneuron to contribute its expertise in neurodegenerative disease to advance biomarkers for drug development in Alzheimer’s disease

Lausanne, SWITZERLAND and San Francisco, CA, USA, 26 March 2024

Asceneuron SA, a clinical stage biotech company dedicated to targeting the root causes of neurodegenerative diseases, today announces that it has joined the Critical Path Institute’s, Critical Path for Alzheimer’s Disease (CPAD) Consortium. With its highly experienced leadership team and world class Scientific Advisory Board of leading experts in neurodegenerative diseases, Asceneuron is well positioned to contribute to the consortium.

Asceneuron has an exemplary pipeline of O-GlcNAcase (OGA) inhibitors in clinical development that have the potential to halt disease progression in neurodegenerative diseases. Its lead asset, ASN51, is a potential best-in-class, orally administered, OGA inhibitor targeting tau aggregation and will be progressing into Phase II clinical development later this year. The CPAD consortium is proceeding to advance important biomarkers for Alzheimer’s disease (AD), such as tau Positron Emission Tomography (PET) and is accelerating the pathway for approval of promising new therapies. As a member of CPAD, Asceneuron will work collaboratively with the consortium to help address the large unmet medical need of patients and families suffering due to neurodegenerative diseases.

Ryan Schubert, Senior Vice President Research and Development at Asceneuron, said:
“We are honored to be collaborating with the CPAD consortium alongside esteemed fellow members, all of whom are dedicated to accelerating drug development to improve patients’ lives. CPAD has gathered high quality data and experts from industry, academia and regulatory agencies with a focus on bringing new treatment options to patients suffering with AD. We look forward to contributing to and impacting the treatment pathway for AD as we advance our lead intracellular tau-targeting asset, ASN51, into Phase II clinical development later this year. Further information will be shared at upcoming scientific conferences.”

Yashmin Karten, PhD, MBA, Associate Director at Critical Path for Alzheimer’s Disease, added: “C-Path is proud to welcome Asceneuron as the newest member of its CPAD Consortium. Asceneuron’s research on molecules that prevent the formation of toxic tau aggregates in the brain to slow down or stop the progrecision-making tools to advance drug development and improve the lives of those living with AD and related dementia (ADRD).

CPAD’s mission is to accelerate the drug development process for patients with chronic neurodegenerative disease leading to dementia. Its primary focus is on AD. CPAD works with industry, regulatory authorities, academia, and patient advocacy organizations to aggregate anonymized patient-level data consensus standards with the aim of advancing drug development tools for evaluating drug efficacy and safety, to optimize novel clinical trial designs, and facilitating the regulatory review process.”
CPAD’s integrated and standardized patient-level database comprises over 100,000 patient level records across 73 separate clinical trial datasets. These records are utilized by over 370 institutions worldwide. Alongside its biotech and pharmaceutical company members, the initiative incorporates feedback from all its stakeholders, including government and regulatory agencies. CPAD has ongoing efforts as part of its pre-competitive working groups to evaluate the potential of tau PET as a reliable surrogate endpoint, with the aim of enhancing efficiency in Alzheimer’s disease drug development.

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For further information, please contact:

Asceneuron
Barbara Angehrn Pavik, CEO
Sandra Millet, Head of Operations
Email: asce-contact@asceneuron.com

Optimum Strategic Communications
Zoe Bolt
Tel: +44 (0) 20 388 296 21
Email: asceneuron@optimumcomms.com

About Asceneuron

Asceneuron is a clinical stage biotech company focused on the development of orally bioavailable therapeutics for debilitating neurodegenerative disorders with high unmet medical need. The company’s pipeline reflects its ambition and commitment to developing treatments for a wide a range of neurodegenerative diseases including Alzheimer’s and Parkinson’s disease, as well as orphan tauopathies. Asceneuron has two clinical-stage small molecule O-GlcNAcase inhibitors in development for the treatment of proteinopathies: OGA inhibitor ASN90 (licensed to Ferrer Pharmaceuticals) for the treatment of progressive supranuclear palsy (PSP) and a potential best-in-class OGA inhibitor, ASN51 for Alzheimer’s disease. Asceneuron is backed by a renowned syndicate of investors consisting of Sofinnova Partners, M Ventures, SR One, Johnson & Johnson Innovation – JJDC, Inc. (JJDC) and Kurma Partners. For more information, please visit www.asceneuron.com.

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Industry Veteran Abbas Hussain Appointed as Chair of Asceneuron

Industry Veteran Abbas Hussain Appointed as Chair of Asceneuron

Further strengthening of leadership team following the appointment of industry stalwart Barbara Angehrn Pavik as Chief Executive Officer

Accelerating advancement of novel treatments to halt disease progression in neurodegenerative diseases

Lausanne, SWITZERLAND and San Francisco, CA, USA, 18 December 2023 – Asceneuron SA, a clinical stage biotech company dedicated to targeting the root causes of neurodegenerative diseases with its exemplary pipeline of O-GlcNAcase (OGA) inhibitors, is pleased to announce the appointment of Abbas Hussain as new Chair to its Board of Directors.

Abbas Hussain has over 35 years of experience in the healthcare industry, building and growing businesses across the globe. He has a strong track record across the pharmaceutical value chain in both mature and emerging markets. Abbas has held various senior leadership positions at world leading pharma companies including GlaxoSmithKline, where he was President of Global Pharmaceuticals with responsibilities for operations in Europe, US, Asia and emerging markets and Eli Lilly, where he was President of Europe. He was Chief Executive Officer of Vifor Pharma which was acquired by CSL Limited in 2022 for $11.7 billion in one of the largest health care deals of the year.

Henrijette Richter, Managing Partner of Sofinnova Partners and Vice Chair of the Board of Directors of Asceneuron, commented: “Abbas has fantastic experience and a proven track record in the pharma industry which will be invaluable as we take Asceneuron into its next stage of growth and accelerate development of these potentially transformative therapies. On behalf of the whole board and company, I would like to thank Peter Van Vlasselaer for his expertise and guidance over the past 5 years.”

Barbara Angehrn Pavik, Chief Executive Officer of Asceneuron, said: “The recent significant advances in neurodegeneration therapies have reinvigorated interest and excitement in this challenging field. We are delighted to welcome Abbas. His experience will be invaluable as we further advance our lead clinical OGA inhibitors into the next stage of development for the benefit of patients.”

Abbas Hussain, Chair of the Board of Directors of Asceneuron, remarked: “There have been tremendous advances in the treatment of neurodegenerative disorders which impact millions of people globally every year. Asceneuron is developing potentially transformative therapies that have the potential to slow disease progression and I am delighted to be joining the team at a pivotal time of transition and growth.”

 

Abbas currently holds various Non-Executive Director and Advisor roles at Alfasigma SpA, 4Bio Capital, C-Bridge Capital and GLG Institute. He previously held various Non-Executive Director roles at Cochlear Limited, CSL Limited, Teva Pharmaceutical, Immunocore and advisory roles with Hikma Plc, Cell Research Corp, Abingworth and Indegene Inc. In addition, Abbas also provides expert advisory services to private equity and venture capital firms focused on the healthcare sector.

He holds a Bachelor of Science in Medicinal and Pharmaceutical Chemistry from Loughborough Institute of Technology (UK) and is a graduate of the Stanford Executive Program at Stanford University (California, USA).

 

Asceneuron’s evolving pipeline is focused on new chemical entities designed to address the high unmet medical needs of neurodegenerative proteinopathies such as Alzheimer’s and Parkinson’s disease. Its proprietary clinical pipeline consists of in-house developed OGA inhibitor ASN90 and potential best-in-class OGA inhibitor ASN51 which are demonstrating potential as a game changer in halting disease progression in neurodegenerative diseases.

Asceneuron’s leadership team will be attending the upcoming 42nd Annual J.P. Morgan Healthcare Conference in San Francisco, 8-11 January 2024.

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For further information, please contact:

Asceneuron
Barbara Angehrn Pavik, CEO
Sandra Millet, Head of Operations
Email: asce-contact@asceneuron.com

Optimum Strategic Communications
Mary Clark, Zoe Bolt, Joshua Evans
Tel: +44 (0) 20 388 296 21 
Email: asceneuron@optimumcomms.com

About Asceneuron

Asceneuron is a clinical stage biotech company focused on the development of orally bioavailable therapeutics for debilitating neurodegenerative disorders with high unmet medical need. The company’s pipeline reflects its ambition and commitment to developing treatments for a wide a range of neurodegenerative diseases including Alzheimer’s and Parkinson’s disease, as well as orphan tauopathies. Asceneuron has two clinical-stage small molecule O-GlcNAcase inhibitors in development for the treatment of proteinopathies: OGA inhibitor ASN90 (licensed to Ferrer Pharmaceuticals) for the treatment of progressive supranuclear palsy (PSP) and a potential best-in-class OGA inhibitor, ASN51 for Alzheimer’s disease. Asceneuron is backed by a renowned syndicate of investors consisting of Sofinnova Partners, M Ventures, SR One, Johnson & Johnson Innovation – JJDC, Inc. (JJDC) and Kurma Partners. For more information, please visit www.asceneuron.com.

Asceneuron Welcomes Barbara Angehrn Pavik as New CEO as It Gears Up for Next Phase of Growth

Asceneuron Welcomes Barbara Angehrn Pavik as New CEO as It Gears Up for Next Phase of Growth

Lausanne, SWITZERLAND, 6 Oct. 2023 – Asceneuron SA, a clinical stage company dedicated to targeting the root causes of neurodegenerative diseases, today announced the appointment of Barbara Angehrn Pavik as the new Chief Executive Officer (CEO), as part of a leadership transition poised to propel the company into its next phase of growth, with two compounds in clinical development.

Dirk Beher, co-founder of Asceneuron, its original Chief Scientific Officer, and CEO since 2014, will transition to the key role of Chief Scientific Advisor.

“Dirk’s leadership and unwavering dedication has been a cornerstone of Asceneuron, enabling the company to become a true pioneer in our field,” said Peter Van Vlasselaer, the Board Chair. “With interest in this therapeutic area accelerating, we’re seeing a surge in momentum for the company and an opportune moment to bolster Asceneuron’s position. Barbara’s appointment will help us capitalize on this pivotal moment.”

Angehrn Pavik is an industry stalwart with more than 20 years of experience who has held key leadership roles in EU and US companies, including Amgen, Onyx, Exelixis, and was the Founder and CEO of Stepstone Pharma. Most recently, as the Chief Business Officer at Vifor, Angehrn Pavik played a key role in the company’s acquisition by CSL Limited.

“I am deeply honored to be joining the Asceneuron team at this transformative juncture,” Angehrn Pavik said. “Moving into clinical development is a pivotal step, and I’m eager to build on the strong foundation laid by Dirk and the Asceneuron team.”

Beher added, “It’s been a journey of passion and commitment at Asceneuron, and I am confident that under Barbara’s leadership, the company will soar to new heights. I look forward to supporting her vision in my capacity as the Chief Scientific Advisor.”

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For media inquiries, please contact:
Barbara Angehrn Pavik
Chief Executive Officer, Asceneuron
barbara.angehrn@asceneuron.com

 

About Asceneuron

Asceneuron is a clinical stage biotech company focused on the development of orally bioavailable therapeutics for debilitating neurodegenerative disorders with high unmet medical need. The company’s pipeline reflects its ambition and commitment to developing treatments for a wide a range of neurodegenerative diseases including Alzheimer’s and Parkinson’s disease, as well as orphan tauopathies. Asceneuron has two clinical-stage small molecule O-GlcNAcase inhibitors in development for the treatment of proteinopathies: OGA inhibitor ASN90 (licensed to Ferrer Pharmaceuticals) for the treatment of progressive supranuclear palsy (PSP) and a potential best-in-class OGA inhibitor, ASN51 for Alzheimer’s disease. Asceneuron is backed by a renowned syndicate of investors consisting of Sofinnova Partners, M Ventures, SR One, Johnson & Johnson Innovation – JJDC, Inc. (JJDC) and Kurma Partners. For more information, please visit www.asceneuron.com.

Asceneuron Awarded Second Grant from The Michael J. Fox Foundation for Accelerated Research into Novel Parkinson’s Disease Therapies

Asceneuron Awarded Second Grant from The Michael J. Fox Foundation for Accelerated Research into Novel Parkinson’s Disease Therapies

Lausanne, SWITZERLAND and San Francisco, CA, USA, 4 May 2022 – Asceneuron SA, a clinical stage company dedicated to targeting the root causes of neurodegenerative diseases, today announces that it has been awarded a second grant from The Michael J. Fox Foundation for Parkinson’s Research (MJFF) to accelerate the study of its clinical stage O-GlcNAcase (OGA) inhibitor ASN51 as a potential new treatment for Parkinson’s disease (PD).

Parkinson’s disease is caused by a loss of dopamine producing nerve cells in the substantia nigra. This leads to a reduction in the signalling mediated by the neurotransmitter dopamine in the brain causing the characteristic motoric dysfunction in PD. An estimated seven to 10 million people worldwide suffer from PD. Although there is no current cure for PD, Asceneuron is discovering and developing therapeutics for the high unmet medical needs of patients experiencing neurodegenerative disorders.
 

The grant will fund a preclinical proof-of-concept study to assess the disease-modifying properties of Asceneuron’s OGA inhibitor ASN51 in a preclinical model of inherited PD. The genetic model is characterized by the overexpression of a-synuclein harbouring the A53T mutation known to cause early-onset, familial PD in humans. Aggregated forms of a-synuclein are the main component of the characteristic Lewy body pathology and thus thought to be causative of the loss of dopaminergic neurons in PD.
 

The aim of this study is to extend previously published findings demonstrating a reduction of motor impairment with Asceneuron’s OGA inhibitors (e.g., Permanne et al., ACS Chem. Neurosci. 2022) to this alternative genetic disease model. The results will further interrogate the mechanism of action of OGA inhibitors with respect to a-synuclein toxicity and aggregation and provide support for the clinical exploration of ASN51 in PD patients. The project will begin immediately, with results expected in the fourth quarter of 2022.
 

Dirk Beher, Chief Executive Officer, Co-Founder of Asceneuron, commented: “We are pleased to have been awarded further funding support from The Michael J. Fox Foundation to progress research on our next generation O-GlcNAcase inhibitor ASN51. ASN51 has the potential to make a meaningful impact on patients suffering with Parkinson’s disease to improve quality of life and slow progression. We are proud to receive the continued support from a foundation that contributes meaningfully towards development of improved therapies for those living with Parkinson’s disease.”
 

“The Michael J. Fox Foundation is dedicated to unlocking the complex biology of Parkinson’s disease and unearth novel breakthrough treatments to improve patient lives and slow disease progression,” said Luis Oliveira, PhD, Senior Associate Director of Research Programs, MJFF. “We are pleased to award Asceneuron a grant to support further research in the O-GlcNAcase inhibitor, ASN51, as a potential modifier of a-synuclein toxicity.”

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For further information, please contact:

Asceneuron
Dirk Beher, CEO
Sandra Millet, Executive Coordinator
Email: asce-contact@asceneuron.com 

Optimum Strategic Communications
Supriya Mathur, Manel Mateus, Zoe Bolt
Tel: +44 (0) 20 388 296 21
Email: asceneuron@optimumcomms.com 

About Asceneuron

Asceneuron is a clinical stage biotech company focused on the development of orally bioavailable therapeutics for debilitating neurodegenerative disorders with high unmet medical need. The company’s pipeline reflects its ambition and commitment to developing treatments for a wide a range of neurodegenerative diseases including Alzheimer’s and Parkinson’s disease, as well as orphan tauopathies. Asceneuron has two clinical-stage small molecule O-GlcNAcase inhibitors in development for the treatment of proteinopathies: OGA inhibitor ASN90 (licensed to Ferrer Pharmaceuticals) for the treatment of progressive supranuclear palsy (PSP) and a potential best-in-class OGA inhibitor, ASN51 for Alzheimer’s disease. Asceneuron is backed by a renowned syndicate of investors consisting of Sofinnova Partners, M Ventures, SR One, Johnson & Johnson Innovation – JJDC, Inc. (JJDC) and Kurma Partners. For more information, please visit www.asceneuron.com.

Ferrer acquires worldwide rights to ASN90, an O-GlcNAcase inhibitor from Asceneuron, exclusively to treat Progressive Supranuclear Palsy (PSP)

Ferrer acquires worldwide rights to ASN90, an O-GlcNAcase inhibitor from Asceneuron, exclusively to treat Progressive Supranuclear Palsy (PSP)

  • ASN90, an O-GlcNAcase inhibitor, is a new chemical entity at clinical stage and a promising candidate for the treatment of PSP, a disorder with a high unmet medical need
  • PSP is a rare neurological condition that causes severe problems with walking, balance, speech, swallowing and vision. As the disease progresses, it causes severe disability within three to five years of onset1
  • ASN90 in PSP is ready to start phase II of clinical development

Barcelona (Spain) / Lausanne (Switzerland), February 22nd, 2023 – Spanish pharmaceutical company Ferrer and Swiss clinical stage biotechnology company Asceneuron announce the signing of a licensing agreement in which Ferrer obtains the exclusive worldwide rights to develop and commercialize ASN90 in progressive supranuclear palsy (PSP), an orphan, tau-related disease with a high unmet medical need1.

Both Ferrer and Asceneuron are pleased that this announcement occurs in close occurrence with Rare Disease Day (February 28). This agreement underscores the commitments both companies have undertaken to improve the lives of patients with a rare disease, such as PSP.

The terms of the agreement include an upfront fee and multiple development, regulatory and commercial milestone payments. Asceneuron is also eligible to receive tiered double-digit royalties on worldwide net sales of ASN90. 

Mario Rovirosa, Ferrer’s Chief Executive Officer, stated: “This is yet another meaningful example of how Ferrer moves forward guided by its purpose of making a positive impact in society. As a B Corp company, we are proud of our people’s commitment to delivering the best possible solutions for those in need.”

Dirk Beher, Chief Executive Officer and Co-Founder of Asceneuron, commented: “This licensing agreement with Ferrer is important news for patients suffering from PSP and their families. Asceneuron, as a neurodegeneration-focused company, will continue expanding the application of OGA mechanism in other diseases in addition to developing further programs in some of the largest unmet medical need indications in neurology.”

Oscar Pérez, Chief Business Development and Global Alliances Officer at Ferrer, added: “Researching a cure for such a devastating condition that lacks available therapeutic options fits perfectly with Ferrer’s mission to develop transformative treatments. We are seeking to generate life-changing solutions for people with PSP. ASN90 is a very promising addition to our growing portfolio in neurological disorders, making Ferrer an increasingly relevant player in the field of neuroscience.”

Ferrer will now conduct a phase II clinical study to determine the efficacy and optimal dose range of ASN90.
SVB Securities acted as exclusive financial advisor to Asceneuron.

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About progressive supranuclear palsy

PSP is a rare neurological condition which typically presents at around 60 years of age and causes severe problems related to walking, balance, speech, swallowing and vision as a result of the accumulation of aggregates of the tau protein in the brain1,2. The disease gets progressively worse, causing severe disability within three to five years of onset. It is estimated that three to six people per 100,0001 will develop PSP and there is currently no known cure for the disease1,2

About Asceneuron

Asceneuron is a clinical stage biotech company focused on the development of orally bioavailable therapeutics for debilitating neurodegenerative disorders with high unmet medical need. The pipeline reflects its ambition to develop treatments for a wide a range of neurodegenerative diseases including orphan tauopathies, Alzheimer’s and Parkinson’s disease. Asceneuron has two clinical stage small molecule O-GlcNAcase inhibitors in development for the treatment of proteinopathies including one first in class for Parkinson’s disease, one best in class in Alzheimer’s disease and related disorders.
For more information, please visit www.asceneuron.com

About Ferrer

At Ferrer we make a positive impact in society and meet the highest standards of social and environmental performance, transparency and corporate responsibility in every territory with a direct presence. That is why in 2022 we became a B Corp® company and a Great Place to Work®.
In order to fulfil our purpose, we offer transformative therapeutic solutions, with an increasing focus on pulmonary vascular and interstitial lung diseases and neurological disorders.
Founded in Barcelona in 1959, our products are present in more than a hundred countries, and we have a team of over 1,700 people. Professionals that we empower and accompany in their learning and wellbeing so that they are proud of working at Ferrer.
We are Ferrer. Ferrer for good.
www.ferrer.com

 

1. Coughlin DG, Litvan I. Progressive supranuclear palsy: Advances in diagnosis and management. Parkinsonism Relat Disord. 2020 Apr;73:105-116. doi: 10.1016/j.parkreldis.2020.04.014. Epub 2020 May 25.

2. Lopez G, Bayulkem K, Hallett M. Progressive supranuclear palsy (PSP): Richardson syndrome and other PSP variants. Acta Neurol Scand. 2016 Oct;134(4):242-9. doi: 10.1111/ane.12546. Epub 2016 Jan 6.